diff --git a/moto/dynamodb2/models.py b/moto/dynamodb2/models.py
index df8c89b72..5b1992cdc 100644
--- a/moto/dynamodb2/models.py
+++ b/moto/dynamodb2/models.py
@@ -203,6 +203,9 @@ class Item(BaseModel):
 
                         last_val = self.attrs[attr].value
                         for key_part in key_parts[:-1]:
+                            list_index_update = re.match('(.+)\\[([0-9]+)\\]', key_part)
+                            if list_index_update:
+                                key_part = list_index_update.group(1)  # listattr[1] ==> listattr
                             # Hack but it'll do, traverses into a dict
                             last_val_type = list(last_val.keys())
                             if last_val_type and last_val_type[0] == 'M':
@@ -212,6 +215,8 @@ class Item(BaseModel):
                                 last_val[key_part] = {'M': {}}
 
                             last_val = last_val[key_part]
+                            if list_index_update:
+                                last_val = last_val['L'][int(list_index_update.group(2))]
 
                         last_val_type = list(last_val.keys())
                         list_index_update = re.match('(.+)\\[([0-9]+)\\]', key_parts[-1])
diff --git a/tests/test_dynamodb2/test_dynamodb.py b/tests/test_dynamodb2/test_dynamodb.py
index 356be7817..b4fb5e8c8 100644
--- a/tests/test_dynamodb2/test_dynamodb.py
+++ b/tests/test_dynamodb2/test_dynamodb.py
@@ -2361,7 +2361,6 @@ def test_update_list_index__set_index_of_a_string():
                            UpdateExpression='set itemstr[1]=:Item',
                            ExpressionAttributeValues={':Item': {'S': 'string_update'}})
         result = client.get_item(TableName=table_name, Key={'id': {'S': 'foo2'}})['Item']
-        print(result)
 
     ex.exception.response['Error']['Code'].should.equal('ValidationException')
     ex.exception.response['Error']['Message'].should.equal(
@@ -2392,6 +2391,26 @@ def test_remove_list_index__remove_existing_nested_index():
     assert result['itemmap']['M']['itemlist']['L'] == [{'S': 'bar1'}]
 
 
+@mock_dynamodb2
+def test_remove_list_index__remove_existing_double_nested_index():
+    table_name = 'test_list_index_access'
+    client = create_table_with_list(table_name)
+    client.put_item(TableName=table_name,
+                    Item={'id': {'S': 'foo2'},
+                          'itemmap': {'M': {'itemlist': {'L': [{'M': {'foo00': {'S': 'bar1'},
+                                                                      'foo01': {'S': 'bar2'}}},
+                                                               {'M': {'foo10': {'S': 'bar1'},
+                                                                      'foo11': {'S': 'bar2'}}}]}}}})
+    client.update_item(TableName=table_name, Key={'id': {'S': 'foo2'}},
+                       UpdateExpression='REMOVE itemmap.itemlist[1].foo10')
+    #
+    result = client.get_item(TableName=table_name, Key={'id': {'S': 'foo2'}})['Item']
+    assert result['id'] == {'S': 'foo2'}
+    assert result['itemmap']['M']['itemlist']['L'][0]['M'].should.equal({'foo00': {'S': 'bar1'},
+                                                                         'foo01': {'S': 'bar2'}})  # untouched
+    assert result['itemmap']['M']['itemlist']['L'][1]['M'].should.equal({'foo11': {'S': 'bar2'}})  # changed
+
+
 @mock_dynamodb2
 def test_remove_list_index__remove_index_out_of_range():
     table_name = 'test_list_index_access'