diff --git a/.github/workflows/test_outdated_versions.yml b/.github/workflows/test_outdated_versions.yml
index f6cf99322..155b275f9 100644
--- a/.github/workflows/test_outdated_versions.yml
+++ b/.github/workflows/test_outdated_versions.yml
@@ -13,8 +13,9 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
+        botocore: ["--upgrade boto3 botocore", "boto3==1.11.0 botocore==1.14.0"]
         python-version: [ "3.11" ]
-        responses-version: ["0.13.0", "0.15.0", "0.17.0", "0.19.0", "0.20.0" ]
+        responses-version: ["0.15.0", "0.17.0", "0.19.0", "0.20.0" ]
         werkzeug-version: ["2.0.1", "2.1.1", "2.2.2"]
         openapi-spec-validator-version: ["0.5.0"]
 
@@ -38,6 +39,7 @@ jobs:
         pip install flask==${{ matrix.werkzeug-version }}
         pip install werkzeug==${{ matrix.werkzeug-version }}
         pip install openapi-spec-validator==${{ matrix.openapi-spec-validator-version }}
+        pip install ${{ matrix.botocore }}
 
     - name: Run tests
       run: |
@@ -65,6 +67,6 @@ jobs:
       if: always()
       uses: actions/upload-artifact@v4
       with:
-        name: test-${{ matrix.responses-version }}-${{ matrix.werkzeug-version }}-${{ matrix.werkzeug-version }}-${{ matrix.openapi-spec-validator-version }}
+        name: test-${{ matrix.responses-version }}-${{ matrix.werkzeug-version }}-${{ matrix.werkzeug-version }}-${{ matrix.openapi-spec-validator-version }}-${{ matrix.botocore }}
         path: |
           serverlogs/*
diff --git a/moto/__init__.py b/moto/__init__.py
index 4d86b3e0d..5a3682e25 100644
--- a/moto/__init__.py
+++ b/moto/__init__.py
@@ -2,18 +2,3 @@ from moto.core.decorator import mock_aws  # noqa  # pylint: disable=unused-impor
 
 __title__ = "moto"
 __version__ = "4.2.15.dev"
-
-
-try:
-    # Need to monkey-patch botocore requests back to underlying urllib3 classes
-    from botocore.awsrequest import (  # type: ignore[attr-defined]
-        HTTPConnection,
-        HTTPConnectionPool,
-        HTTPSConnectionPool,
-        VerifiedHTTPSConnection,
-    )
-except ImportError:
-    pass
-else:
-    HTTPSConnectionPool.ConnectionCls = VerifiedHTTPSConnection
-    HTTPConnectionPool.ConnectionCls = HTTPConnection
diff --git a/moto/core/versions.py b/moto/core/versions.py
index 07769fed6..cc2a6dba6 100644
--- a/moto/core/versions.py
+++ b/moto/core/versions.py
@@ -13,5 +13,9 @@ def is_responses_0_17_x() -> bool:
     return LooseVersion(RESPONSES_VERSION) >= LooseVersion("0.17.0")
 
 
+def is_werkzeug_2_0_x_or_older() -> bool:
+    return LooseVersion(WERKZEUG_VERSION) < LooseVersion("2.1.0")
+
+
 def is_werkzeug_2_3_x() -> bool:
     return LooseVersion(WERKZEUG_VERSION) >= LooseVersion("2.3.0")
diff --git a/setup.cfg b/setup.cfg
index 8d24d68e5..1318959b1 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -27,13 +27,13 @@ project_urls =
 python_requires = >=3.8
 install_requires =
     boto3>=1.9.201
-    botocore>=1.13.46
+    botocore>=1.14.0
     cryptography>=3.3.1
     requests>=2.5
     xmltodict
     werkzeug>=0.5,!=2.2.0,!=2.2.1
     python-dateutil<3.0.0,>=2.1
-    responses>=0.13.0
+    responses>=0.15.0
     Jinja2>=2.10.1
 package_dir =
     moto = moto
diff --git a/tests/test_awslambda/test_lambda.py b/tests/test_awslambda/test_lambda.py
index 5476728fd..3bcffa387 100644
--- a/tests/test_awslambda/test_lambda.py
+++ b/tests/test_awslambda/test_lambda.py
@@ -2,6 +2,7 @@ import base64
 import hashlib
 import json
 import os
+import sys
 from unittest import SkipTest, mock
 from uuid import uuid4
 
@@ -12,6 +13,7 @@ from freezegun import freeze_time
 
 from moto import mock_aws, settings
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
 from tests.test_ecr.test_ecr_helpers import _create_image_manifest
 
 from . import lambda_aws_verified
@@ -28,6 +30,8 @@ PYTHON_VERSION = "python3.11"
 LAMBDA_FUNC_NAME = "test"
 _lambda_region = "us-west-2"
 
+boto3_version = sys.modules["botocore"].__version__
+
 
 @mock.patch.dict("os.environ", {"MOTO_ENABLE_ISO_REGIONS": "true"})
 @pytest.mark.parametrize("region", ["us-west-2", "cn-northwest-1", "us-isob-east-1"])
@@ -35,6 +39,8 @@ _lambda_region = "us-west-2"
 def test_lambda_regions(region):
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest("Can only set EnvironVars in DecoratorMode")
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("ISO-region not available in older versions")
     client = boto3.client("lambda", region_name=region)
     resp = client.list_functions()
     assert resp["ResponseMetadata"]["HTTPStatusCode"] == 200
@@ -43,6 +49,8 @@ def test_lambda_regions(region):
 @pytest.mark.aws_verified
 @lambda_aws_verified
 def test_list_functions(iam_role_arn=None):
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     sts = boto3.client("sts", "eu-west-2")
     account_id = sts.get_caller_identity()["Account"]
 
@@ -70,7 +78,9 @@ def test_list_functions(iam_role_arn=None):
     func_list = conn.list_functions()["Functions"]
     our_functions = [f for f in func_list if f["FunctionName"] == function_name]
     assert len(our_functions) == 1
-    assert our_functions[0]["PackageType"] == "Zip"
+    if LooseVersion(boto3_version) > LooseVersion("1.29.0"):
+        # PackageType only available in new versions
+        assert our_functions[0]["PackageType"] == "Zip"
 
     # FunctionVersion=ALL means we should get a list of all versions
     full_list = conn.list_functions(FunctionVersion="ALL")["Functions"]
@@ -127,6 +137,8 @@ def test_create_based_on_s3_with_missing_bucket():
 @mock_aws
 @freeze_time("2015-01-01 00:00:00")
 def test_create_function_from_aws_bucket():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     bucket_name = str(uuid4())
     s3_conn = boto3.client("s3", _lambda_region)
     s3_conn.create_bucket(
@@ -169,6 +181,8 @@ def test_create_function_from_aws_bucket():
 @mock_aws
 @freeze_time("2015-01-01 00:00:00")
 def test_create_function_from_zipfile():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     zip_content = get_test_zip_file1()
     function_name = str(uuid4())[0:6]
@@ -218,6 +232,8 @@ def test_create_function_from_zipfile():
 
 @mock_aws
 def test_create_function_from_image():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     function_name = str(uuid4())[0:6]
     image_uri = f"{ACCOUNT_ID}.dkr.ecr.us-east-1.amazonaws.com/testlambdaecr:prod"
@@ -237,9 +253,6 @@ def test_create_function_from_image():
         Description="test lambda function",
         ImageConfig=image_config,
         PackageType="Image",
-        Timeout=3,
-        MemorySize=128,
-        Publish=True,
     )
 
     result = conn.get_function(FunctionName=function_name)
@@ -250,6 +263,8 @@ def test_create_function_from_image():
 
 @mock_aws
 def test_create_function_from_image_default_working_directory():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     function_name = str(uuid4())[0:6]
     image_uri = f"{ACCOUNT_ID}.dkr.ecr.us-east-1.amazonaws.com/testlambdaecr:prod"
@@ -268,9 +283,6 @@ def test_create_function_from_image_default_working_directory():
         Description="test lambda function",
         ImageConfig=image_config,
         PackageType="Image",
-        Timeout=3,
-        MemorySize=128,
-        Publish=True,
     )
 
     result = conn.get_function(FunctionName=function_name)
@@ -281,6 +293,8 @@ def test_create_function_from_image_default_working_directory():
 
 @mock_aws
 def test_create_function_error_bad_architecture():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     function_name = str(uuid4())[0:6]
     image_uri = f"{ACCOUNT_ID}.dkr.ecr.us-east-1.amazonaws.com/testlambdaecr:prod"
@@ -291,10 +305,6 @@ def test_create_function_error_bad_architecture():
             FunctionName=function_name,
             Role=get_role_name(),
             Code={"ImageUri": image_uri},
-            Description="test lambda function",
-            Timeout=3,
-            MemorySize=128,
-            Publish=True,
         )
 
     err = exc.value.response
@@ -310,6 +320,8 @@ def test_create_function_error_bad_architecture():
 
 @mock_aws
 def test_create_function_error_ephemeral_too_big():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     function_name = str(uuid4())[0:6]
     image_uri = f"{ACCOUNT_ID}.dkr.ecr.us-east-1.amazonaws.com/testlambdaecr:prod"
@@ -405,6 +417,8 @@ def ecr_repo_fixture():
 
 @mock_aws
 def test_create_function_from_stubbed_ecr():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     lambda_client = boto3.client("lambda", "us-east-1")
     fn_name = str(uuid4())[0:6]
     image_uri = "111122223333.dkr.ecr.us-east-1.amazonaws.com/testlambda:latest"
@@ -440,6 +454,8 @@ def test_create_function_from_stubbed_ecr():
 def test_create_function_from_mocked_ecr_image_tag(
     with_ecr_mock,
 ):  # pylint: disable=unused-argument
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest(
             "Envars not easily set in server mode, feature off by default, skipping..."
@@ -482,6 +498,8 @@ def test_create_function_from_mocked_ecr_image_tag(
 def test_create_function_from_mocked_ecr_image_digest(
     with_ecr_mock,
 ):  # pylint: disable=unused-argument
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest(
             "Envars not easily set in server mode, feature off by default, skipping..."
@@ -509,6 +527,8 @@ def test_create_function_from_mocked_ecr_image_digest(
 def test_create_function_from_mocked_ecr_missing_image(
     with_ecr_mock,
 ):  # pylint: disable=unused-argument
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest(
             "Envars not easily set in server mode, feature off by default, skipping..."
@@ -696,6 +716,8 @@ def test_get_function_configuration(key):
 @pytest.mark.parametrize("key", ["FunctionName", "FunctionArn"])
 @mock_aws
 def test_get_function_code_signing_config(key):
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     bucket_name = str(uuid4())
     s3_conn = boto3.client("s3", _lambda_region)
     s3_conn.create_bucket(
@@ -929,6 +951,8 @@ def test_list_create_list_get_delete_list():
     test `list -> create -> list -> get -> delete -> list` integration
 
     """
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     bucket_name = str(uuid4())
     s3_conn = boto3.client("s3", _lambda_region)
     s3_conn.create_bucket(
@@ -1055,9 +1079,6 @@ def test_get_function_created_with_zipfile():
         Handler="lambda_function.handler",
         Code={"ZipFile": zip_content},
         Description="test lambda function",
-        Timeout=3,
-        MemorySize=128,
-        Publish=True,
     )
 
     response = conn.get_function(FunctionName=function_name)
@@ -1503,6 +1524,8 @@ def test_update_function_s3():
 
 @mock_aws
 def test_update_function_ecr():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     function_name = str(uuid4())[0:6]
     image_uri = f"{ACCOUNT_ID}.dkr.ecr.us-east-1.amazonaws.com/testlambdaecr:prod"
diff --git a/tests/test_awslambda/test_lambda_function_urls.py b/tests/test_awslambda/test_lambda_function_urls.py
index f583332e4..37e875c17 100644
--- a/tests/test_awslambda/test_lambda_function_urls.py
+++ b/tests/test_awslambda/test_lambda_function_urls.py
@@ -1,3 +1,5 @@
+import sys
+from unittest import SkipTest
 from uuid import uuid4
 
 import boto3
@@ -5,15 +7,20 @@ import pytest
 from botocore.exceptions import ClientError
 
 from moto import mock_aws
+from moto.utilities.distutils_version import LooseVersion
 
 from .utilities import get_role_name, get_test_zip_file1
 
 PYTHON_VERSION = "python3.11"
 
+boto3_version = sys.modules["botocore"].__version__
+
 
 @mock_aws
 @pytest.mark.parametrize("key", ["FunctionName", "FunctionArn"])
 def test_create_function_url_config(key):
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     client = boto3.client("lambda", "us-east-2")
     function_name = str(uuid4())[0:6]
     fxn = client.create_function(
@@ -40,6 +47,8 @@ def test_create_function_url_config(key):
 
 @mock_aws
 def test_create_function_url_config_with_cors():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     client = boto3.client("lambda", "us-east-2")
     function_name = str(uuid4())[0:6]
     fxn = client.create_function(
@@ -75,6 +84,8 @@ def test_create_function_url_config_with_cors():
 
 @mock_aws
 def test_update_function_url_config_with_cors():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     client = boto3.client("lambda", "us-east-2")
     function_name = str(uuid4())[0:6]
     fxn = client.create_function(
@@ -108,6 +119,8 @@ def test_update_function_url_config_with_cors():
 @mock_aws
 @pytest.mark.parametrize("key", ["FunctionName", "FunctionArn"])
 def test_delete_function_url_config(key):
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     client = boto3.client("lambda", "us-east-2")
     function_name = str(uuid4())[0:6]
     fxn = client.create_function(
diff --git a/tests/test_awslambda/test_lambda_layers.py b/tests/test_awslambda/test_lambda_layers.py
index 701adb915..5e751997c 100644
--- a/tests/test_awslambda/test_lambda_layers.py
+++ b/tests/test_awslambda/test_lambda_layers.py
@@ -1,4 +1,5 @@
 import os
+import sys
 from unittest import SkipTest, mock
 from uuid import uuid4
 
@@ -9,12 +10,15 @@ from freezegun import freeze_time
 
 from moto import mock_aws, settings
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
 
 from .utilities import get_role_name, get_test_zip_file1
 
 PYTHON_VERSION = "python3.11"
 _lambda_region = "us-west-2"
 
+boto3_version = sys.modules["botocore"].__version__
+
 
 @mock_aws
 def test_publish_lambda_layers__without_content():
@@ -50,6 +54,8 @@ def test_publish_layer_with_unknown_s3_file():
 @mock_aws
 @freeze_time("2015-01-01 00:00:00")
 def test_get_lambda_layers():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     bucket_name = str(uuid4())
     s3_conn = boto3.client("s3", _lambda_region)
     s3_conn.create_bucket(
@@ -152,6 +158,8 @@ def test_get_lambda_layers():
 
 @mock_aws
 def test_get_layer_version():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     bucket_name = str(uuid4())
     s3_conn = boto3.client("s3", _lambda_region)
     s3_conn.create_bucket(
diff --git a/tests/test_awslambda/test_lambda_policy.py b/tests/test_awslambda/test_lambda_policy.py
index df038282d..524f28254 100644
--- a/tests/test_awslambda/test_lambda_policy.py
+++ b/tests/test_awslambda/test_lambda_policy.py
@@ -1,4 +1,6 @@
 import json
+import sys
+from unittest import SkipTest
 from uuid import uuid4
 
 import boto3
@@ -7,12 +9,15 @@ from botocore.exceptions import ClientError
 
 from moto import mock_aws
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
 
 from .utilities import get_role_name, get_test_zip_file1, get_test_zip_file2
 
 PYTHON_VERSION = "python3.11"
 _lambda_region = "us-west-2"
 
+boto3_version = sys.modules["botocore"].__version__
+
 
 @pytest.mark.parametrize("key", ["FunctionName", "FunctionArn"])
 @mock_aws
@@ -51,6 +56,8 @@ def test_add_function_permission(key):
 
 @mock_aws
 def test_add_permission_with_principalorgid():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     conn = boto3.client("lambda", _lambda_region)
     zip_content = get_test_zip_file1()
     function_name = str(uuid4())[0:6]
diff --git a/tests/test_cloudformation/test_cloudformation_stack_crud_boto3.py b/tests/test_cloudformation/test_cloudformation_stack_crud_boto3.py
index d6c37aa67..7706a0286 100644
--- a/tests/test_cloudformation/test_cloudformation_stack_crud_boto3.py
+++ b/tests/test_cloudformation/test_cloudformation_stack_crud_boto3.py
@@ -1,6 +1,7 @@
 import copy
 import json
 import os
+import sys
 from collections import OrderedDict
 from datetime import datetime, timedelta, timezone
 from unittest import SkipTest
@@ -12,11 +13,14 @@ from botocore.exceptions import ClientError
 from moto import mock_aws, settings
 from moto.cloudformation import cloudformation_backends
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
 from tests import EXAMPLE_AMI_ID
 
 TEST_STACK_NAME = "test_stack"
 REGION_NAME = "us-east-1"
 
+boto3_version = sys.modules["botocore"].__version__
+
 dummy_template = {
     "AWSTemplateFormatVersion": "2010-09-09",
     "Description": "Stack 1",
@@ -367,7 +371,9 @@ def test_describe_stack_instances():
     for instance in [use1_instance, usw2_instance]:
         assert instance["Account"] == ACCOUNT_ID
         assert instance["Status"] == "CURRENT"
-        assert instance["StackInstanceStatus"] == {"DetailedStatus": "SUCCEEDED"}
+        if LooseVersion(boto3_version) > LooseVersion("1.29.0"):
+            # "Parameters only available in newer versions"
+            assert instance["StackInstanceStatus"] == {"DetailedStatus": "SUCCEEDED"}
 
 
 @mock_aws
@@ -1615,6 +1621,8 @@ def test_delete_change_set():
 
 @mock_aws
 def test_create_change_set_twice__no_changes():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     cf_client = boto3.client("cloudformation", region_name=REGION_NAME)
 
     # Execute once
@@ -1646,6 +1654,8 @@ def test_create_change_set_twice__no_changes():
 
 @mock_aws
 def test_create_change_set_twice__using_s3__no_changes():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameters only available in newer versions")
     cf_client = boto3.client("cloudformation", region_name=REGION_NAME)
     s3 = boto3.client("s3", region_name=REGION_NAME)
     s3_conn = boto3.resource("s3", region_name=REGION_NAME)
diff --git a/tests/test_cloudformation/test_cloudformation_stack_integration.py b/tests/test_cloudformation/test_cloudformation_stack_integration.py
index 534ec31f7..3be5d3083 100644
--- a/tests/test_cloudformation/test_cloudformation_stack_integration.py
+++ b/tests/test_cloudformation/test_cloudformation_stack_integration.py
@@ -1,5 +1,6 @@
 import io
 import json
+import sys
 import zipfile
 from decimal import Decimal
 from string import Template
@@ -10,10 +11,13 @@ from botocore.exceptions import ClientError
 
 from moto import mock_aws
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
 from tests import EXAMPLE_AMI_ID, EXAMPLE_AMI_ID2
 from tests.markers import requires_docker
 from tests.test_cloudformation.fixtures import fn_join, single_instance_with_ebs_volume
 
+boto3_version = sys.modules["botocore"].__version__
+
 
 @mock_aws
 def test_create_template_without_required_param_boto3():
@@ -274,18 +278,19 @@ def lambda_handler(event, context):
     lambda_conn = boto3.client("lambda", region)
     result = lambda_conn.list_layers()
     layer_name = result["Layers"][0]["LayerName"]
-    result = lambda_conn.list_layer_versions(LayerName=layer_name)
-    result["LayerVersions"][0].pop("CreatedDate")
-    assert result["LayerVersions"] == [
-        {
-            "Version": 1,
-            "LayerVersionArn": f"arn:aws:lambda:{region}:{ACCOUNT_ID}:layer:{layer_name}:1",
-            "CompatibleRuntimes": ["python2.7", "python3.6"],
-            "Description": "Test Layer",
-            "LicenseInfo": "MIT",
-            "CompatibleArchitectures": [],
-        }
-    ]
+    lv = lambda_conn.list_layer_versions(LayerName=layer_name)["LayerVersions"][0]
+
+    assert lv["Version"] == 1
+    assert (
+        lv["LayerVersionArn"]
+        == f"arn:aws:lambda:{region}:{ACCOUNT_ID}:layer:{layer_name}:1"
+    )
+    assert lv["CompatibleRuntimes"] == ["python2.7", "python3.6"]
+    assert lv["Description"] == "Test Layer"
+    assert lv["LicenseInfo"] == "MIT"
+    if LooseVersion(boto3_version) > LooseVersion("1.29.0"):
+        # "Parameters only available in newer versions"
+        assert lv["CompatibleArchitectures"] == []
 
 
 @mock_aws
diff --git a/tests/test_core/test_auth.py b/tests/test_core/test_auth.py
index 4813fb420..9dedf9040 100644
--- a/tests/test_core/test_auth.py
+++ b/tests/test_core/test_auth.py
@@ -1,5 +1,7 @@
 import json
+import sys
 from typing import Any, Dict, Optional
+from unittest import SkipTest
 from uuid import uuid4
 
 import boto3
@@ -9,6 +11,9 @@ from botocore.exceptions import ClientError
 from moto import mock_aws
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
 from moto.core import set_initial_no_auth_action_count
+from moto.utilities.distutils_version import LooseVersion
+
+boto3_version = sys.modules["botocore"].__version__
 
 
 @mock_aws
@@ -191,6 +196,8 @@ def test_invalid_client_token_id() -> None:
 @set_initial_no_auth_action_count(0)
 @mock_aws
 def test_auth_failure() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     client = boto3.client(
         "ec2",
         region_name="us-east-1",
@@ -230,6 +237,8 @@ def test_signature_does_not_match() -> None:
 @set_initial_no_auth_action_count(2)
 @mock_aws
 def test_auth_failure_with_valid_access_key_id() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     access_key = create_user_with_access_key()
     client = boto3.client(
         "ec2",
@@ -250,6 +259,8 @@ def test_auth_failure_with_valid_access_key_id() -> None:
 @set_initial_no_auth_action_count(2)
 @mock_aws
 def test_access_denied_with_no_policy() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     user_name = "test-user"
     access_key = create_user_with_access_key(user_name)
     client = boto3.client(
@@ -271,6 +282,8 @@ def test_access_denied_with_no_policy() -> None:
 @set_initial_no_auth_action_count(3)
 @mock_aws
 def test_access_denied_with_not_allowing_policy() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     user_name = "test-user"
     inline_policy_document = {
         "Version": "2012-10-17",
@@ -339,6 +352,8 @@ def test_access_denied_explicitly_on_specific_resource() -> None:
 @set_initial_no_auth_action_count(3)
 @mock_aws
 def test_access_denied_for_run_instances() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     # https://github.com/getmoto/moto/issues/2774
     # The run-instances method was broken between botocore versions 1.15.8 and 1.15.12
     # This was due to the inclusion of '"idempotencyToken":true' in the response, somehow altering the signature and breaking the authentication
@@ -372,6 +387,8 @@ def test_access_denied_for_run_instances() -> None:
 @set_initial_no_auth_action_count(3)
 @mock_aws
 def test_access_denied_with_denying_policy() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     user_name = "test-user"
     inline_policy_document = {
         "Version": "2012-10-17",
@@ -533,6 +550,8 @@ def test_s3_access_denied_with_denying_inline_group_policy() -> None:
 @set_initial_no_auth_action_count(10)
 @mock_aws
 def test_access_denied_with_many_irrelevant_policies() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     user_name = "test-user"
     inline_policy_document = {
         "Version": "2012-10-17",
diff --git a/tests/test_core/test_ec2_vpc_endpoint_services.py b/tests/test_core/test_ec2_vpc_endpoint_services.py
index b804da1f1..9b0ce6515 100644
--- a/tests/test_core/test_ec2_vpc_endpoint_services.py
+++ b/tests/test_core/test_ec2_vpc_endpoint_services.py
@@ -3,11 +3,16 @@
 #
 # There are some issues with running these tests in parallel
 # Running them as part of 'moto/core' avoids that problem
+import sys
+
 import boto3
 import pytest
 from botocore.exceptions import ClientError
 
 from moto import mock_aws
+from moto.utilities.distutils_version import LooseVersion
+
+boto3_version = sys.modules["botocore"].__version__
 
 
 @mock_aws
@@ -103,9 +108,11 @@ def test_describe_vpc_default_endpoint_services() -> None:
     assert details["ManagesVpcEndpoints"] is False
     assert details["Owner"] == "amazon"
     assert details["PrivateDnsName"] == "config.us-west-1.amazonaws.com"
-    assert details["PrivateDnsNames"] == [
-        {"PrivateDnsName": "config.us-west-1.amazonaws.com"}
-    ]
+    if LooseVersion(boto3_version) > LooseVersion("1.29.0"):
+        # Attribute wasn't available in older botocore versions
+        assert details["PrivateDnsNames"] == [
+            {"PrivateDnsName": "config.us-west-1.amazonaws.com"}
+        ]
     assert details["PrivateDnsNameVerificationState"] == "verified"
     assert details["ServiceName"] == "com.amazonaws.us-west-1.config"
     assert details["ServiceType"] == [{"ServiceType": "Interface"}]
diff --git a/tests/test_core/test_importorder.py b/tests/test_core/test_importorder.py
index e235f553a..7c4569c1e 100644
--- a/tests/test_core/test_importorder.py
+++ b/tests/test_core/test_importorder.py
@@ -1,3 +1,4 @@
+import sys
 from typing import Any, List
 from unittest import SkipTest
 
@@ -5,6 +6,9 @@ import boto3
 import pytest
 
 from moto import mock_aws, settings
+from moto.utilities.distutils_version import LooseVersion
+
+boto3_version = sys.modules["botocore"].__version__
 
 
 @pytest.fixture(scope="function", name="aws_credentials")
@@ -70,6 +74,8 @@ def test_mock_works_with_resource_created_outside(
 
 
 def test_patch_can_be_called_on_a_mocked_client() -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     # start S3 after the mock, ensuring that the client contains our event-handler
     m = mock_aws()
     m.start()
@@ -118,6 +124,8 @@ class ImportantBusinessLogic:
 def test_mock_works_when_replacing_client(
     aws_credentials: Any,  # pylint: disable=unused-argument
 ) -> None:
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Error handling is different in newer versions")
     logic = ImportantBusinessLogic()
 
     m = mock_aws()
diff --git a/tests/test_core/test_request_passthrough.py b/tests/test_core/test_request_passthrough.py
index 16867d8cc..a563a9856 100644
--- a/tests/test_core/test_request_passthrough.py
+++ b/tests/test_core/test_request_passthrough.py
@@ -8,11 +8,16 @@ import requests
 from botocore.exceptions import ClientError
 
 from moto import mock_aws, settings
+from moto.core.versions import is_werkzeug_2_0_x_or_older
 
 
 def test_passthrough_calls_for_entire_service() -> None:
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest("Can only test config when using decorators")
+    if is_werkzeug_2_0_x_or_older():
+        raise SkipTest(
+            "Bug in old werkzeug versions where headers with byte-values throw errors"
+        )
     # Still mock the credentials ourselves, we don't want to reach out to AWS for real
     with patch.dict(
         os.environ, {"AWS_ACCESS_KEY_ID": "a", "AWS_SECRET_ACCESS_KEY": "b"}
@@ -50,6 +55,10 @@ def test_passthrough_calls_for_entire_service() -> None:
 def test_passthrough_calls_for_specific_url() -> None:
     if not settings.TEST_DECORATOR_MODE:
         raise SkipTest("Can only test config when using decorators")
+    if is_werkzeug_2_0_x_or_older():
+        raise SkipTest(
+            "Bug in old werkzeug versions where headers with byte-values throw errors"
+        )
     # Still mock the credentials ourselves, we don't want to reach out to AWS for real
     with patch.dict(
         os.environ, {"AWS_ACCESS_KEY_ID": "a", "AWS_SECRET_ACCESS_KEY": "b"}
@@ -135,9 +144,9 @@ def test_passthrough__using_unsupported_service() -> None:
                 }
             }
         ):
-            b2bi = boto3.client("b2bi", "us-east-1")
+            workdocs = boto3.client("workdocs", "us-east-1")
             with pytest.raises(ClientError) as exc:
-                b2bi.list_transformers()
+                workdocs.describe_users()
             assert "Not yet implemented" in str(exc.value)
 
 
diff --git a/tests/test_iotdata/test_iotdata.py b/tests/test_iotdata/test_iotdata.py
index 73a5e4d1b..60e58c081 100644
--- a/tests/test_iotdata/test_iotdata.py
+++ b/tests/test_iotdata/test_iotdata.py
@@ -1,4 +1,6 @@
 import json
+import sys
+from unittest import SkipTest
 
 import boto3
 import pytest
@@ -7,6 +9,9 @@ from botocore.exceptions import ClientError
 import moto.iotdata.models
 from moto import mock_aws, settings
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+from moto.utilities.distutils_version import LooseVersion
+
+boto3_version = sys.modules["botocore"].__version__
 
 
 @mock_aws
@@ -94,6 +99,8 @@ def test_update():
 
 @mock_aws
 def test_create_named_shadows():
+    if LooseVersion(boto3_version) < LooseVersion("1.29.0"):
+        raise SkipTest("Parameter only available in newer versions")
     iot_client = boto3.client("iot", region_name="ap-northeast-1")
     client = boto3.client("iot-data", region_name="ap-northeast-1")
     thing_name = "my-thing"