diff --git a/moto/s3/responses.py b/moto/s3/responses.py
index 1b32698e4..e3660dea2 100755
--- a/moto/s3/responses.py
+++ b/moto/s3/responses.py
@@ -18,10 +18,10 @@ from .exceptions import BucketAlreadyExists, S3ClientError, MissingBucket, Missi
     MalformedACLError
 from .models import s3_backend, get_canned_acl, FakeGrantee, FakeGrant, FakeAcl, FakeKey, FakeTagging, FakeTagSet, \
     FakeTag
-from .utils import bucket_name_from_url, metadata_from_headers
+from .utils import bucket_name_from_url, metadata_from_headers, parse_region_from_url
 from xml.dom import minidom
 
-REGION_URL_REGEX = r'\.s3-(.+?)\.amazonaws\.com'
+
 DEFAULT_REGION_NAME = 'us-east-1'
 
 
@@ -128,10 +128,7 @@ class ResponseObject(_TemplateEnvironmentMixin):
         parsed_url = urlparse(full_url)
         querystring = parse_qs(parsed_url.query, keep_blank_values=True)
         method = request.method
-        region_name = DEFAULT_REGION_NAME
-        region_match = re.search(REGION_URL_REGEX, full_url)
-        if region_match:
-            region_name = region_match.groups()[0]
+        region_name = parse_region_from_url(full_url)
 
         bucket_name = self.parse_bucket_name_from_url(request, full_url)
         if not bucket_name:
diff --git a/moto/s3/utils.py b/moto/s3/utils.py
index a121eae3a..8968d2ad2 100644
--- a/moto/s3/utils.py
+++ b/moto/s3/utils.py
@@ -1,4 +1,5 @@
 from __future__ import unicode_literals
+import logging
 
 from boto.s3.key import Key
 import re
@@ -6,6 +7,10 @@ import six
 from six.moves.urllib.parse import urlparse, unquote
 import sys
 
+
+log = logging.getLogger(__name__)
+
+
 bucket_name_regex = re.compile("(.+).s3(.*).amazonaws.com")
 
 
@@ -27,6 +32,20 @@ def bucket_name_from_url(url):
             return None
 
 
+REGION_URL_REGEX = re.compile(
+    r'^https?://(s3[-\.](?P<region1>.+)\.amazonaws\.com/(.+)|'
+    r'(.+)\.s3-(?P<region2>.+)\.amazonaws\.com)/?')
+
+
+def parse_region_from_url(url):
+    match = REGION_URL_REGEX.search(url)
+    if match:
+        region = match.group('region1') or match.group('region2')
+    else:
+        region = 'us-east-1'
+    return region
+
+
 def metadata_from_headers(headers):
     metadata = {}
     meta_regex = re.compile(
diff --git a/tests/test_s3/test_s3_utils.py b/tests/test_s3/test_s3_utils.py
index b4f56d89a..f1dfc04d1 100644
--- a/tests/test_s3/test_s3_utils.py
+++ b/tests/test_s3/test_s3_utils.py
@@ -1,6 +1,6 @@
 from __future__ import unicode_literals
 from sure import expect
-from moto.s3.utils import bucket_name_from_url, _VersionedKeyStore
+from moto.s3.utils import bucket_name_from_url, _VersionedKeyStore, parse_region_from_url
 
 
 def test_base_url():
@@ -53,3 +53,21 @@ def test_versioned_key_store():
     d.setlist('key', [[1], [2]])
     d['key'].should.have.length_of(1)
     d.getlist('key').should.be.equal([[1], [2]])
+
+
+def test_parse_region_from_url():
+    expected = 'us-west-2'
+    for url in ['http://s3-us-west-2.amazonaws.com/bucket',
+                'http://s3.us-west-2.amazonaws.com/bucket',
+                'http://bucket.s3-us-west-2.amazonaws.com',
+                'https://s3-us-west-2.amazonaws.com/bucket',
+                'https://s3.us-west-2.amazonaws.com/bucket',
+                'https://bucket.s3-us-west-2.amazonaws.com']:
+        parse_region_from_url(url).should.equal(expected)
+
+    expected = 'us-east-1'
+    for url in ['http://s3.amazonaws.com/bucket',
+                'http://bucket.s3.amazonaws.com',
+                'https://s3.amazonaws.com/bucket',
+                'https://bucket.s3.amazonaws.com']:
+        parse_region_from_url(url).should.equal(expected)