diff --git a/moto/iam/models.py b/moto/iam/models.py
index 57d24826d..32ca144c3 100644
--- a/moto/iam/models.py
+++ b/moto/iam/models.py
@@ -349,6 +349,14 @@ class User(BaseModel):
             raise IAMNotFoundException(
                 "Key {0} not found".format(access_key_id))
 
+    def update_access_key(self, access_key_id, status):
+        for key in self.access_keys:
+            if key.access_key_id == access_key_id:
+                key.status = status
+                break
+        else:
+            raise IAMNotFoundException("The Access Key with id {0} cannot be found".format(access_key_id))
+
     def get_cfn_attribute(self, attribute_name):
         from moto.cloudformation.exceptions import UnformattedGetAttTemplateException
         if attribute_name == 'Arn':
@@ -817,6 +825,10 @@ class IAMBackend(BaseBackend):
         key = user.create_access_key()
         return key
 
+    def update_access_key(self, user_name, access_key_id, status):
+        user = self.get_user(user_name)
+        user.update_access_key(access_key_id, status)
+
     def get_all_access_keys(self, user_name, marker=None, max_items=None):
         user = self.get_user(user_name)
         keys = user.get_all_access_keys()
diff --git a/moto/iam/responses.py b/moto/iam/responses.py
index 0e11c09d5..9931cb8d0 100644
--- a/moto/iam/responses.py
+++ b/moto/iam/responses.py
@@ -440,6 +440,14 @@ class IamResponse(BaseResponse):
         template = self.response_template(CREATE_ACCESS_KEY_TEMPLATE)
         return template.render(key=key)
 
+    def update_access_key(self):
+        user_name = self._get_param('UserName')
+        access_key_id = self._get_param('AccessKeyId')
+        status = self._get_param('Status')
+        iam_backend.update_access_key(user_name, access_key_id, status)
+        template = self.response_template(GENERIC_EMPTY_TEMPLATE)
+        return template.render(name='UpdateAccessKey')
+
     def list_access_keys(self):
         user_name = self._get_param('UserName')
 
diff --git a/tests/test_iam/test_iam.py b/tests/test_iam/test_iam.py
index d50f6999e..b4dfe532d 100644
--- a/tests/test_iam/test_iam.py
+++ b/tests/test_iam/test_iam.py
@@ -651,3 +651,21 @@ def test_attach_detach_user_policy():
 
     resp = client.list_attached_user_policies(UserName=user.name)
     resp['AttachedPolicies'].should.have.length_of(0)
+
+
+@mock_iam
+def test_update_access_key():
+    iam = boto3.resource('iam', region_name='us-east-1')
+    client = iam.meta.client
+    username = 'test-user'
+    iam.create_user(UserName=username)
+    with assert_raises(ClientError):
+        client.update_access_key(UserName=username,
+                                 AccessKeyId='non-existent-key',
+                                 Status='Inactive')
+    key = client.create_access_key(UserName=username)['AccessKey']
+    client.update_access_key(UserName=username,
+                             AccessKeyId=key['AccessKeyId'],
+                             Status='Inactive')
+    resp = client.list_access_keys(UserName=username)
+    resp['AccessKeyMetadata'][0]['Status'].should.equal('Inactive')