diff --git a/moto/resourcegroupstaggingapi/models.py b/moto/resourcegroupstaggingapi/models.py
index bd63847a0..1cf38e8d1 100644
--- a/moto/resourcegroupstaggingapi/models.py
+++ b/moto/resourcegroupstaggingapi/models.py
@@ -3,6 +3,7 @@ import uuid
 import six
 from boto3 import Session
 
+from moto.core import ACCOUNT_ID
 from moto.core import BaseBackend
 from moto.core.exceptions import RESTError
 
@@ -367,6 +368,23 @@ class ResourceGroupsTaggingAPIBackend(BaseBackend):
         # RedShift Subnet group
 
         # VPC
+        if (
+            not resource_type_filters
+            or "ec2" in resource_type_filters
+            or "ec2:vpc" in resource_type_filters
+        ):
+            for vpc in self.ec2_backend.vpcs.values():
+                tags = get_ec2_tags(vpc.id)
+                if not tags or not tag_filter(
+                    tags
+                ):  # Skip if no tags, or invalid filter
+                    continue
+                yield {
+                    "ResourceARN": "arn:aws:ec2:{0}:{1}:vpc/{2}".format(
+                        self.region_name, ACCOUNT_ID, vpc.id
+                    ),
+                    "Tags": tags,
+                }
         # VPC Customer Gateway
         # VPC DHCP Option Set
         # VPC Internet Gateway
diff --git a/tests/test_resourcegroupstaggingapi/test_resourcegroupstaggingapi.py b/tests/test_resourcegroupstaggingapi/test_resourcegroupstaggingapi.py
index 154744a14..f5a934b9b 100644
--- a/tests/test_resourcegroupstaggingapi/test_resourcegroupstaggingapi.py
+++ b/tests/test_resourcegroupstaggingapi/test_resourcegroupstaggingapi.py
@@ -61,6 +61,27 @@ def test_get_resources_ec2():
     resp["ResourceTagMappingList"][0]["ResourceARN"].should.contain("instance/")
 
 
+@mock_ec2
+@mock_resourcegroupstaggingapi
+def test_get_resources_ec2_vpc():
+    ec2 = boto3.resource("ec2", region_name="us-west-1")
+    vpc = ec2.create_vpc(CidrBlock="10.0.0.0/16")
+    ec2.create_tags(Resources=[vpc.id], Tags=[{"Key": "test", "Value": "test"}])
+
+    def assert_response(resp):
+        results = resp.get("ResourceTagMappingList", [])
+        results.should.have.length_of(1)
+        vpc.id.should.be.within(results[0]["ResourceARN"])
+
+    rtapi = boto3.client("resourcegroupstaggingapi", region_name="us-west-1")
+    resp = rtapi.get_resources(ResourceTypeFilters=["ec2"])
+    assert_response(resp)
+    resp = rtapi.get_resources(ResourceTypeFilters=["ec2:vpc"])
+    assert_response(resp)
+    resp = rtapi.get_resources(TagFilters=[{"Key": "test", "Values": ["test"]}])
+    assert_response(resp)
+
+
 @mock_ec2
 @mock_resourcegroupstaggingapi
 def test_get_tag_keys_ec2():