diff --git a/moto/dynamodb2/responses.py b/moto/dynamodb2/responses.py
index fba153c6f..e1d669c58 100644
--- a/moto/dynamodb2/responses.py
+++ b/moto/dynamodb2/responses.py
@@ -179,8 +179,20 @@ class DynamoHandler(BaseResponse):
         # getting attribute definition
         attr = body["AttributeDefinitions"]
         # getting the indexes
-        global_indexes = body.get("GlobalSecondaryIndexes", [])
-        local_secondary_indexes = body.get("LocalSecondaryIndexes", [])
+        global_indexes = body.get("GlobalSecondaryIndexes")
+        if global_indexes == []:
+            return self.error(
+                "ValidationException",
+                "One or more parameter values were invalid: List of GlobalSecondaryIndexes is empty",
+            )
+        global_indexes = global_indexes or []
+        local_secondary_indexes = body.get("LocalSecondaryIndexes")
+        if local_secondary_indexes == []:
+            return self.error(
+                "ValidationException",
+                "One or more parameter values were invalid: List of LocalSecondaryIndexes is empty",
+            )
+        local_secondary_indexes = local_secondary_indexes or []
         # Verify AttributeDefinitions list all
         expected_attrs = []
         expected_attrs.extend([key["AttributeName"] for key in key_schema])
diff --git a/tests/test_dynamodb2/exceptions/test_dynamodb_exceptions.py b/tests/test_dynamodb2/exceptions/test_dynamodb_exceptions.py
index c241f3bd9..61b5e0354 100644
--- a/tests/test_dynamodb2/exceptions/test_dynamodb_exceptions.py
+++ b/tests/test_dynamodb2/exceptions/test_dynamodb_exceptions.py
@@ -428,3 +428,41 @@ def test_hash_key_can_only_use_equals_operations(operator):
     err = exc.value.response["Error"]
     err["Code"].should.equal("ValidationException")
     err["Message"].should.equal("Query key condition not supported")
+
+
+@mock_dynamodb2
+def test_creating_table_with_0_local_indexes():
+    dynamodb = boto3.resource("dynamodb", region_name="us-east-1")
+
+    with pytest.raises(ClientError) as exc:
+        dynamodb.create_table(
+            TableName="test-table",
+            KeySchema=[{"AttributeName": "pk", "KeyType": "HASH"}],
+            AttributeDefinitions=[{"AttributeName": "pk", "AttributeType": "S"}],
+            ProvisionedThroughput={"ReadCapacityUnits": 1, "WriteCapacityUnits": 1},
+            LocalSecondaryIndexes=[],
+        )
+    err = exc.value.response["Error"]
+    err["Code"].should.equal("ValidationException")
+    err["Message"].should.equal(
+        "One or more parameter values were invalid: List of LocalSecondaryIndexes is empty"
+    )
+
+
+@mock_dynamodb2
+def test_creating_table_with_0_global_indexes():
+    dynamodb = boto3.resource("dynamodb", region_name="us-east-1")
+
+    with pytest.raises(ClientError) as exc:
+        dynamodb.create_table(
+            TableName="test-table",
+            KeySchema=[{"AttributeName": "pk", "KeyType": "HASH"}],
+            AttributeDefinitions=[{"AttributeName": "pk", "AttributeType": "S"}],
+            ProvisionedThroughput={"ReadCapacityUnits": 1, "WriteCapacityUnits": 1},
+            GlobalSecondaryIndexes=[],
+        )
+    err = exc.value.response["Error"]
+    err["Code"].should.equal("ValidationException")
+    err["Message"].should.equal(
+        "One or more parameter values were invalid: List of GlobalSecondaryIndexes is empty"
+    )