diff --git a/moto/dynamodb2/responses.py b/moto/dynamodb2/responses.py
index 15c1130f8..d07beefd6 100644
--- a/moto/dynamodb2/responses.py
+++ b/moto/dynamodb2/responses.py
@@ -1,4 +1,5 @@
 from __future__ import unicode_literals
+import itertools
 import json
 import six
 import re
@@ -113,6 +114,21 @@ class DynamoHandler(BaseResponse):
         # getting the indexes
         global_indexes = body.get("GlobalSecondaryIndexes", [])
         local_secondary_indexes = body.get("LocalSecondaryIndexes", [])
+        # Verify AttributeDefinitions list all
+        expected_attrs = []
+        expected_attrs.extend([key['AttributeName'] for key in key_schema])
+        expected_attrs.extend(schema['AttributeName'] for schema in itertools.chain(*list(idx['KeySchema'] for idx in local_secondary_indexes)))
+        expected_attrs.extend(schema['AttributeName'] for schema in itertools.chain(*list(idx['KeySchema'] for idx in global_indexes)))
+        expected_attrs = list(set(expected_attrs))
+        expected_attrs.sort()
+        actual_attrs = [item['AttributeName'] for item in attr]
+        actual_attrs.sort()
+        if actual_attrs != expected_attrs:
+            er = 'com.amazonaws.dynamodb.v20111205#ValidationException'
+            return self.error(er,
+                              'One or more parameter values were invalid: '
+                              'Some index key attributes are not defined in AttributeDefinitions. '
+                              'Keys: ' + str(expected_attrs) + ', AttributeDefinitions: ' + str(actual_attrs))
         # get the stream specification
         streams = body.get("StreamSpecification")
 
diff --git a/tests/test_dynamodb2/test_dynamodb.py b/tests/test_dynamodb2/test_dynamodb.py
index 4e7b2dfeb..b0952f101 100644
--- a/tests/test_dynamodb2/test_dynamodb.py
+++ b/tests/test_dynamodb2/test_dynamodb.py
@@ -1676,15 +1676,7 @@ def test_query_global_secondary_index_when_created_via_update_table_resource():
             {
                 'AttributeName': 'user_id',
                 'AttributeType': 'N',
-            },
-            {
-                'AttributeName': 'forum_name',
-                'AttributeType': 'S'
-            },
-            {
-                'AttributeName': 'subject',
-                'AttributeType': 'S'
-            },
+            }
         ],
         ProvisionedThroughput={
             'ReadCapacityUnits': 5,
@@ -2258,6 +2250,34 @@ def test_batch_items_should_throw_exception_for_duplicate_request():
     ex.exception.response['Error']['Message'].should.equal('Provided list of item keys contains duplicates')
 
 
+@mock_dynamodb2
+def test_index_with_unknown_attributes_should_fail():
+    dynamodb = boto3.client('dynamodb', region_name='us-east-1')
+
+    expected_exception = 'Some index key attributes are not defined in AttributeDefinitions.'
+
+    with assert_raises(ClientError) as ex:
+        dynamodb.create_table(
+            AttributeDefinitions=[
+                {'AttributeName': 'customer_nr', 'AttributeType': 'S'},
+                {'AttributeName': 'last_name', 'AttributeType': 'S'}],
+            TableName='table_with_missing_attribute_definitions',
+            KeySchema=[
+                {'AttributeName': 'customer_nr', 'KeyType': 'HASH'},
+                {'AttributeName': 'last_name', 'KeyType': 'RANGE'}],
+            LocalSecondaryIndexes=[{
+                'IndexName': 'indexthataddsanadditionalattribute',
+                'KeySchema': [
+                    {'AttributeName': 'customer_nr', 'KeyType': 'HASH'},
+                    {'AttributeName': 'postcode', 'KeyType': 'RANGE'}],
+                'Projection': { 'ProjectionType': 'ALL' }
+            }],
+            BillingMode='PAY_PER_REQUEST')
+
+    ex.exception.response['Error']['Code'].should.equal('ValidationException')
+    ex.exception.response['Error']['Message'].should.contain(expected_exception)
+
+
 def _create_user_table():
     client = boto3.client('dynamodb', region_name='us-east-1')
     client.create_table(
diff --git a/tests/test_dynamodb2/test_dynamodb_table_with_range_key.py b/tests/test_dynamodb2/test_dynamodb_table_with_range_key.py
index e64d7d196..7d1975eda 100644
--- a/tests/test_dynamodb2/test_dynamodb_table_with_range_key.py
+++ b/tests/test_dynamodb2/test_dynamodb_table_with_range_key.py
@@ -1765,6 +1765,14 @@ def test_boto3_update_table_gsi_throughput():
                 'AttributeName': 'subject',
                 'AttributeType': 'S'
             },
+            {
+                'AttributeName': 'username',
+                'AttributeType': 'S'
+            },
+            {
+                'AttributeName': 'created',
+                'AttributeType': 'S'
+            }
         ],
         ProvisionedThroughput={
             'ReadCapacityUnits': 5,
@@ -1939,6 +1947,14 @@ def test_update_table_gsi_throughput():
                 'AttributeName': 'subject',
                 'AttributeType': 'S'
             },
+            {
+                'AttributeName': 'username',
+                'AttributeType': 'S'
+            },
+            {
+                'AttributeName': 'created',
+                'AttributeType': 'S'
+            }
         ],
         ProvisionedThroughput={
             'ReadCapacityUnits': 5,