diff --git a/IMPLEMENTATION_COVERAGE.md b/IMPLEMENTATION_COVERAGE.md
index 5e6ef1c9e..3a18c527e 100644
--- a/IMPLEMENTATION_COVERAGE.md
+++ b/IMPLEMENTATION_COVERAGE.md
@@ -2694,7 +2694,7 @@
 
 ## ec2-instance-connect
 0% implemented
-- [ ] send_ssh_public_key
+- [x] send_ssh_public_key
 
 ## ecr
 27% implemented
diff --git a/moto/__init__.py b/moto/__init__.py
index a9f1bb8ba..7925d1c7e 100644
--- a/moto/__init__.py
+++ b/moto/__init__.py
@@ -21,6 +21,7 @@ from .dynamodb import mock_dynamodb, mock_dynamodb_deprecated  # noqa
 from .dynamodb2 import mock_dynamodb2, mock_dynamodb2_deprecated  # noqa
 from .dynamodbstreams import mock_dynamodbstreams  # noqa
 from .ec2 import mock_ec2, mock_ec2_deprecated  # noqa
+from .ec2_instance_connect import mock_ec2_instance_connect  # noqa
 from .ecr import mock_ecr, mock_ecr_deprecated  # noqa
 from .ecs import mock_ecs, mock_ecs_deprecated  # noqa
 from .elb import mock_elb, mock_elb_deprecated  # noqa
diff --git a/moto/backends.py b/moto/backends.py
index 9295bc758..81790bbaf 100644
--- a/moto/backends.py
+++ b/moto/backends.py
@@ -19,6 +19,7 @@ from moto.dynamodb import dynamodb_backends
 from moto.dynamodb2 import dynamodb_backends2
 from moto.dynamodbstreams import dynamodbstreams_backends
 from moto.ec2 import ec2_backends
+from moto.ec2_instance_connect import ec2_instance_connect_backends
 from moto.ecr import ecr_backends
 from moto.ecs import ecs_backends
 from moto.elb import elb_backends
@@ -71,6 +72,7 @@ BACKENDS = {
     "dynamodb2": dynamodb_backends2,
     "dynamodbstreams": dynamodbstreams_backends,
     "ec2": ec2_backends,
+    "ec2_instance_connect": ec2_instance_connect_backends,
     "ecr": ecr_backends,
     "ecs": ecs_backends,
     "elb": elb_backends,
diff --git a/moto/ec2/urls.py b/moto/ec2/urls.py
index b83a9e950..4d85b2f56 100644
--- a/moto/ec2/urls.py
+++ b/moto/ec2/urls.py
@@ -2,6 +2,6 @@ from __future__ import unicode_literals
 from .responses import EC2Response
 
 
-url_bases = ["https?://ec2.(.+).amazonaws.com(|.cn)"]
+url_bases = ["https?://ec2\.(.+)\.amazonaws\.com(|\.cn)"]
 
 url_paths = {"{0}/": EC2Response.dispatch}
diff --git a/moto/ec2_instance_connect/__init__.py b/moto/ec2_instance_connect/__init__.py
new file mode 100644
index 000000000..c20d59cfa
--- /dev/null
+++ b/moto/ec2_instance_connect/__init__.py
@@ -0,0 +1,4 @@
+from ..core.models import base_decorator
+from .models import ec2_instance_connect_backends
+
+mock_ec2_instance_connect = base_decorator(ec2_instance_connect_backends)
diff --git a/moto/ec2_instance_connect/models.py b/moto/ec2_instance_connect/models.py
new file mode 100644
index 000000000..cc8cc3f33
--- /dev/null
+++ b/moto/ec2_instance_connect/models.py
@@ -0,0 +1,11 @@
+import boto
+from moto.core import BaseBackend
+
+
+class Ec2InstanceConnectBackend(BaseBackend):
+    pass
+
+
+ec2_instance_connect_backends = {}
+for region in boto.ec2.regions():
+    ec2_instance_connect_backends[region.name] = Ec2InstanceConnectBackend()
diff --git a/moto/ec2_instance_connect/responses.py b/moto/ec2_instance_connect/responses.py
new file mode 100644
index 000000000..462f1fddc
--- /dev/null
+++ b/moto/ec2_instance_connect/responses.py
@@ -0,0 +1,9 @@
+import json
+from moto.core.responses import BaseResponse
+
+
+class Ec2InstanceConnectResponse(BaseResponse):
+    def send_ssh_public_key(self):
+        return json.dumps(
+            {"RequestId": "example-2a47-4c91-9700-e37e85162cb6", "Success": True}
+        )
diff --git a/moto/ec2_instance_connect/urls.py b/moto/ec2_instance_connect/urls.py
new file mode 100644
index 000000000..e7078264f
--- /dev/null
+++ b/moto/ec2_instance_connect/urls.py
@@ -0,0 +1,6 @@
+from __future__ import unicode_literals
+from .responses import Ec2InstanceConnectResponse
+
+url_bases = ["https?://ec2-instance-connect\.(.+)\.amazonaws\.com"]
+
+url_paths = {"{0}/$": Ec2InstanceConnectResponse.dispatch}
diff --git a/tests/test_ec2_instance_connect/test_ec2_instance_connect_boto3.py b/tests/test_ec2_instance_connect/test_ec2_instance_connect_boto3.py
new file mode 100644
index 000000000..eb685d80a
--- /dev/null
+++ b/tests/test_ec2_instance_connect/test_ec2_instance_connect_boto3.py
@@ -0,0 +1,23 @@
+import boto3
+
+from moto import mock_ec2_instance_connect
+
+pubkey = """ssh-rsa
+AAAAB3NzaC1yc2EAAAADAQABAAABAQDV5+voluw2zmzqpqCAqtsyoP01TQ8Ydx1eS1yD6wUsHcPqMIqpo57YxiC8XPwrdeKQ6GG6MC3bHsgXoPypGP0LyixbiuLTU31DnnqorcHt4bWs6rQa7dK2pCCflz2fhYRt5ZjqSNsAKivIbqkH66JozN0SySIka3kEV79GdB0BicioKeEJlCwM9vvxafyzjWf/z8E0lh4ni3vkLpIVJ0t5l+Qd9QMJrT6Is0SCQPVagTYZoi8+fWDoGsBa8vyRwDjEzBl28ZplKh9tSyDkRIYszWTpmK8qHiqjLYZBfAxXjGJbEYL1iig4ZxvbYzKEiKSBi1ZMW9iWjHfZDZuxXAmB
+example
+"""
+
+
+@mock_ec2_instance_connect
+def test_send_ssh_public_key():
+    client = boto3.client("ec2-instance-connect", region_name="us-east-1")
+    fake_request_id = "example-2a47-4c91-9700-e37e85162cb6"
+
+    response = client.send_ssh_public_key(
+        InstanceId="i-abcdefg12345",
+        InstanceOSUser="ec2-user",
+        SSHPublicKey=pubkey,
+        AvailabilityZone="us-east-1a",
+    )
+
+    assert response["RequestId"] == fake_request_id