diff --git a/tests/test_guardduty/test_guardduty.py b/tests/test_guardduty/test_guardduty.py
index 8ec945b43..4087b79ad 100644
--- a/tests/test_guardduty/test_guardduty.py
+++ b/tests/test_guardduty/test_guardduty.py
@@ -1,6 +1,5 @@
 import boto3
 import pytest
-import sure  # noqa # pylint: disable=unused-import
 
 from botocore.exceptions import ClientError
 from moto import mock_guardduty
@@ -16,16 +15,16 @@ def test_create_detector():
         DataSources={"S3Logs": {"Enable": True}},
         Tags={},
     )
-    response.should.have.key("DetectorId")
-    response["DetectorId"].shouldnt.equal(None)
+    assert "DetectorId" in response
+    assert response["DetectorId"] is not None
 
 
 @mock_guardduty
 def test_create_detector_with_minimal_params():
     client = boto3.client("guardduty", region_name="us-east-1")
     response = client.create_detector(Enable=True)
-    response.should.have.key("DetectorId")
-    response["DetectorId"].shouldnt.equal(None)
+    assert "DetectorId" in response
+    assert response["DetectorId"] is not None
 
 
 @mock_guardduty
@@ -40,10 +39,9 @@ def test_get_detector_with_s3():
     )["DetectorId"]
 
     resp = client.get_detector(DetectorId=detector_id)
-    resp.should.have.key("FindingPublishingFrequency").equals("ONE_HOUR")
-    resp.should.have.key("DataSources")
-    resp["DataSources"].should.have.key("S3Logs").equals({"Status": "ENABLED"})
-    resp.should.have.key("CreatedAt")
+    assert resp["FindingPublishingFrequency"] == "ONE_HOUR"
+    assert resp["DataSources"]["S3Logs"] == {"Status": "ENABLED"}
+    assert "CreatedAt" in resp
 
 
 @mock_guardduty
@@ -61,14 +59,10 @@ def test_get_detector_with_all_data_sources():
     )["DetectorId"]
 
     resp = client.get_detector(DetectorId=detector_id)
-    resp.should.have.key("FindingPublishingFrequency").equals("ONE_HOUR")
-    resp.should.have.key("DataSources")
-    resp["DataSources"].should.have.key("S3Logs").equals({"Status": "ENABLED"})
-    resp["DataSources"].should.have.key("Kubernetes")
-    resp["DataSources"]["Kubernetes"].should.have.key("AuditLogs").equals(
-        {"Status": "ENABLED"}
-    )
-    resp.should.have.key("CreatedAt")
+    assert resp["FindingPublishingFrequency"] == "ONE_HOUR"
+    assert resp["DataSources"]["S3Logs"] == {"Status": "ENABLED"}
+    assert resp["DataSources"]["Kubernetes"]["AuditLogs"] == {"Status": "ENABLED"}
+    assert "CreatedAt" in resp
 
 
 @mock_guardduty
@@ -92,13 +86,9 @@ def test_update_detector():
     )
 
     resp = client.get_detector(DetectorId=detector_id)
-    resp.should.have.key("FindingPublishingFrequency").equals("SIX_HOURS")
-    resp.should.have.key("DataSources")
-    resp["DataSources"].should.have.key("S3Logs").equals({"Status": "ENABLED"})
-    resp["DataSources"].should.have.key("Kubernetes")
-    resp["DataSources"]["Kubernetes"].should.have.key("AuditLogs").equals(
-        {"Status": "DISABLED"}
-    )
+    assert resp["FindingPublishingFrequency"] == "SIX_HOURS"
+    assert resp["DataSources"]["S3Logs"] == {"Status": "ENABLED"}
+    assert resp["DataSources"]["Kubernetes"]["AuditLogs"] == {"Status": "DISABLED"}
 
 
 @mock_guardduty
@@ -106,7 +96,7 @@ def test_list_detectors_initial():
     client = boto3.client("guardduty", region_name="us-east-1")
 
     response = client.list_detectors()
-    response.should.have.key("DetectorIds").equals([])
+    assert response["DetectorIds"] == []
 
 
 @mock_guardduty
@@ -122,8 +112,7 @@ def test_list_detectors():
     d2 = client.create_detector(Enable=False)["DetectorId"]
 
     response = client.list_detectors()
-    response.should.have.key("DetectorIds")
-    set(response["DetectorIds"]).should.equal({d1, d2})
+    assert set(response["DetectorIds"]) == {d1, d2}
 
 
 @mock_guardduty
@@ -147,9 +136,10 @@ def test_delete_detector():
     with pytest.raises(ClientError) as exc:
         client.get_detector(DetectorId=detector_id)
     err = exc.value.response["Error"]
-    err["Code"].should.equal("BadRequestException")
-    err["Message"].should.equal(
-        "The request is rejected because the input detectorId is not owned by the current account."
+    assert err["Code"] == "BadRequestException"
+    assert (
+        err["Message"]
+        == "The request is rejected because the input detectorId is not owned by the current account."
     )
 
-    client.list_detectors().should.have.key("DetectorIds").equals([])
+    assert client.list_detectors()["DetectorIds"] == []
diff --git a/tests/test_guardduty/test_guardduty_filters.py b/tests/test_guardduty/test_guardduty_filters.py
index d3e1335d9..2726c9898 100644
--- a/tests/test_guardduty/test_guardduty_filters.py
+++ b/tests/test_guardduty/test_guardduty_filters.py
@@ -1,6 +1,5 @@
 import boto3
 import pytest
-import sure  # noqa # pylint: disable=unused-import
 
 from botocore.exceptions import ClientError
 from moto import mock_guardduty
@@ -16,7 +15,7 @@ def test_create_filter():
         Name="my first filter",
         FindingCriteria={"Criterion": {"x": {"Eq": ["y"]}}},
     )
-    resp.should.have.key("Name").equals("my first filter")
+    assert resp["Name"] == "my first filter"
 
 
 @mock_guardduty
@@ -31,7 +30,7 @@ def test_create_filter__defaults():
     )
 
     resp = client.get_filter(DetectorId=detector_id, FilterName="my first filter")
-    resp.should.have.key("Rank").equals(1)
+    assert resp["Rank"] == 1
 
 
 @mock_guardduty
@@ -46,8 +45,8 @@ def test_get_filter():
     )
 
     resp = client.get_filter(DetectorId=detector_id, FilterName="my first filter")
-    resp.should.have.key("Name").equals("my first filter")
-    resp.should.have.key("FindingCriteria").equals({"Criterion": {"x": {"Eq": ["y"]}}})
+    assert resp["Name"] == "my first filter"
+    assert resp["FindingCriteria"] == {"Criterion": {"x": {"Eq": ["y"]}}}
 
 
 @mock_guardduty
@@ -68,14 +67,14 @@ def test_update_filter():
         Rank=21,
         Action="NOOP",
     )
-    resp.should.have.key("Name").equals("my first filter")
+    assert resp["Name"] == "my first filter"
 
     resp = client.get_filter(DetectorId=detector_id, FilterName="my first filter")
-    resp.should.have.key("Name").equals("my first filter")
-    resp.should.have.key("Description").equals("with desc")
-    resp.should.have.key("Rank").equals(21)
-    resp.should.have.key("Action").equals("NOOP")
-    resp.should.have.key("FindingCriteria").equals({"Criterion": {"x": {"Eq": ["y"]}}})
+    assert resp["Name"] == "my first filter"
+    assert resp["Description"] == "with desc"
+    assert resp["Rank"] == 21
+    assert resp["Action"] == "NOOP"
+    assert resp["FindingCriteria"] == {"Criterion": {"x": {"Eq": ["y"]}}}
 
 
 @mock_guardduty
@@ -94,4 +93,4 @@ def test_delete_filter():
     with pytest.raises(ClientError) as exc:
         client.get_filter(DetectorId=detector_id, FilterName="my first filter")
     err = exc.value.response["Error"]
-    err["Code"].should.equal("BadRequestException")
+    assert err["Code"] == "BadRequestException"
diff --git a/tests/test_guardduty/test_guardduty_organization.py b/tests/test_guardduty/test_guardduty_organization.py
index 71227462d..e523f490e 100644
--- a/tests/test_guardduty/test_guardduty_organization.py
+++ b/tests/test_guardduty/test_guardduty_organization.py
@@ -1,5 +1,4 @@
 import boto3
-import sure  # noqa # pylint: disable=unused-import
 
 from moto import mock_guardduty
 
@@ -8,8 +7,7 @@ from moto import mock_guardduty
 def test_enable_organization_admin_account():
     client = boto3.client("guardduty", region_name="us-east-1")
     resp = client.enable_organization_admin_account(AdminAccountId="")
-    resp.should.have.key("ResponseMetadata")
-    resp["ResponseMetadata"].should.have.key("HTTPStatusCode").equals(200)
+    assert resp["ResponseMetadata"]["HTTPStatusCode"] == 200
 
 
 @mock_guardduty
@@ -18,7 +16,7 @@ def test_list_organization_admin_accounts():
     client.enable_organization_admin_account(AdminAccountId="someaccount")
 
     resp = client.list_organization_admin_accounts()
-    resp.should.have.key("AdminAccounts").length_of(1)
-    resp["AdminAccounts"].should.contain(
-        {"AdminAccountId": "someaccount", "AdminStatus": "ENABLED"}
-    )
+    assert len(resp["AdminAccounts"]) == 1
+    assert {"AdminAccountId": "someaccount", "AdminStatus": "ENABLED"} in resp[
+        "AdminAccounts"
+    ]
diff --git a/tests/test_guardduty/test_server.py b/tests/test_guardduty/test_server.py
index 4a09532fa..8a24804ca 100644
--- a/tests/test_guardduty/test_server.py
+++ b/tests/test_guardduty/test_server.py
@@ -1,5 +1,4 @@
 import json
-import sure  # noqa # pylint: disable=unused-import
 
 import moto.server as server
 
@@ -10,5 +9,5 @@ def test_create_without_enable_option():
 
     body = {"enable": "True"}
     response = test_client.post("/detector", data=json.dumps(body))
-    response.status_code.should.equal(200)
-    json.loads(response.data).should.have.key("detectorId")
+    assert response.status_code == 200
+    assert "detectorId" in json.loads(response.data)