diff --git a/moto/ec2/models.py b/moto/ec2/models.py
index e22ccb7d2..5995f71ab 100644
--- a/moto/ec2/models.py
+++ b/moto/ec2/models.py
@@ -270,7 +270,7 @@ class TaggedEC2Resource(BaseModel):
 
         value = getattr(self, filter_name.lower().replace("-", "_"), None)
         if value is not None:
-            return [value]
+            return value
 
         raise FilterNotImplementedError(filter_name, method_name)
 
diff --git a/tests/test_ec2/test_amis.py b/tests/test_ec2/test_amis.py
index 525e23f45..2eefa3b12 100644
--- a/tests/test_ec2/test_amis.py
+++ b/tests/test_ec2/test_amis.py
@@ -1339,6 +1339,31 @@ def test_ami_attribute_user_and_group_permissions_boto3():
     image.public.should.equal(False)
 
 
+@mock_ec2
+def test_filter_description():
+    # https://github.com/spulec/moto/issues/4460
+    client = boto3.client("ec2", region_name="us-west-2")
+
+    # Search for partial description
+    resp = client.describe_images(
+        Owners=["amazon"],
+        Filters=[{"Name": "description", "Values": ["Amazon Linux AMI*"]}],
+    )["Images"]
+    resp.should.have.length_of(4)
+
+    # Search for full description
+    resp = client.describe_images(
+        Owners=["amazon"],
+        Filters=[
+            {
+                "Name": "description",
+                "Values": ["Amazon Linux AMI 2018.03.0.20210721.0 x86_64 VPC HVM ebs"],
+            }
+        ],
+    )["Images"]
+    resp.should.have.length_of(1)
+
+
 # Has boto3 equivalent
 @mock_ec2_deprecated
 def test_ami_attribute_error_cases():