diff --git a/moto/iam/models.py b/moto/iam/models.py
index 6a21e0781..1231544cb 100644
--- a/moto/iam/models.py
+++ b/moto/iam/models.py
@@ -957,7 +957,9 @@ class InstanceProfile(CloudFormationModel):
         account_id: str,
         region_name: str,
     ) -> None:
-        iam_backends[account_id]["global"].delete_instance_profile(resource_name)
+        iam_backends[account_id]["global"].delete_instance_profile(
+            resource_name, ignore_attached_roles=True
+        )
 
     def delete_role(self, role_name: str) -> None:
         self.roles = [role for role in self.roles if role.name != role_name]
@@ -2370,9 +2372,11 @@ class IAMBackend(BaseBackend):
         self.instance_profiles[name] = instance_profile
         return instance_profile
 
-    def delete_instance_profile(self, name: str) -> None:
+    def delete_instance_profile(
+        self, name: str, ignore_attached_roles: bool = False
+    ) -> None:
         instance_profile = self.get_instance_profile(name)
-        if len(instance_profile.roles) > 0:
+        if len(instance_profile.roles) > 0 and not ignore_attached_roles:
             raise IAMConflictException(
                 code="DeleteConflict",
                 message="Cannot delete entity, must remove roles from instance profile first.",
diff --git a/tests/test_iam/__init__.py b/tests/test_iam/__init__.py
index 08a1c1568..466103fb0 100644
--- a/tests/test_iam/__init__.py
+++ b/tests/test_iam/__init__.py
@@ -1 +1,28 @@
-# This file is intentionally left blank.
+import os
+from functools import wraps
+
+from moto import mock_aws
+
+
+def iam_aws_verified(func):
+    """
+    Function that is verified to work against AWS.
+    Can be run against AWS at any time by setting:
+      MOTO_TEST_ALLOW_AWS_REQUEST=true
+
+    If this environment variable is not set, the function runs in a `mock_aws` context.
+    """
+
+    @wraps(func)
+    def pagination_wrapper():
+        allow_aws_request = (
+            os.environ.get("MOTO_TEST_ALLOW_AWS_REQUEST", "false").lower() == "true"
+        )
+
+        if allow_aws_request:
+            return func()
+        else:
+            with mock_aws():
+                return func()
+
+    return pagination_wrapper
diff --git a/tests/test_iam/test_iam_cloudformation.py b/tests/test_iam/test_iam_cloudformation.py
index aae856d18..2ac97ff82 100644
--- a/tests/test_iam/test_iam_cloudformation.py
+++ b/tests/test_iam/test_iam_cloudformation.py
@@ -1,4 +1,5 @@
 import json
+from uuid import uuid4
 
 import boto3
 import pytest
@@ -8,6 +9,8 @@ from botocore.exceptions import ClientError
 from moto import mock_aws
 from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
 from tests import EXAMPLE_AMI_ID
+from tests.test_iam import iam_aws_verified
+from tests.test_iam.test_iam import MOCK_STS_EC2_POLICY_DOCUMENT
 
 TEMPLATE_MINIMAL_ROLE = """
 AWSTemplateFormatVersion: 2010-09-09
@@ -1609,3 +1612,46 @@ def test_iam_roles():
         if resource["ResourceType"] == "AWS::IAM::Role"
     ]
     assert {r["PhysicalResourceId"] for r in role_resources} == set(role_names)
+
+
+template_with_instance_profile = """
+Parameters:
+    InputRole:
+        Type: String
+        Default: "test-emr-role"
+
+Resources:
+    emrEc2InstanceProfile:
+        Type: 'AWS::IAM::InstanceProfile'
+        Properties:
+            Path: /
+            Roles:
+              - !Ref InputRole
+"""
+
+
+@iam_aws_verified
+def test_delete_instance_profile_with_existing_role():
+    region = "us-east-1"
+    iam = boto3.client("iam", region_name=region)
+    iam_role_name = f"moto_{str(uuid4())[0:6]}"
+    iam.create_role(
+        RoleName=iam_role_name, AssumeRolePolicyDocument=MOCK_STS_EC2_POLICY_DOCUMENT
+    )
+
+    try:
+        cf = boto3.client("cloudformation", region_name=region)
+        cf.create_stack(
+            StackName="teststack",
+            TemplateBody=template_with_instance_profile,
+            Parameters=[{"ParameterKey": "InputRole", "ParameterValue": iam_role_name}],
+            Capabilities=["CAPABILITY_NAMED_IAM"],
+        )
+
+        # Just verify that we can delete the InstanceProfile
+        cf.delete_stack(StackName="teststack")
+
+        # The role still exists at this point
+        iam.get_role(RoleName=iam_role_name)
+    finally:
+        iam.delete_role(RoleName=iam_role_name)