diff --git a/moto/ec2/models.py b/moto/ec2/models.py
index 039362a92..2aebc463f 100644
--- a/moto/ec2/models.py
+++ b/moto/ec2/models.py
@@ -219,6 +219,10 @@ class InstanceBackend(object):
                 if instance.id in instance_ids:
                     result.append(instance)
 
+        # TODO: Trim error message down to specific invalid id.
+        if instance_ids and len(instance_ids) > len(result):
+            raise InvalidInstanceIdError(instance_ids)
+
         return result
 
     def get_instance_by_id(self, instance_id):
diff --git a/tests/test_ec2/test_instances.py b/tests/test_ec2/test_instances.py
index f032924a1..9f93121c6 100644
--- a/tests/test_ec2/test_instances.py
+++ b/tests/test_ec2/test_instances.py
@@ -277,3 +277,10 @@ def test_describe_instance_status_with_instance_filter():
     all_status = conn.get_all_instance_status(instance_ids=[instance.id])
     len(all_status).should.equal(1)
     all_status[0].id.should.equal(instance.id)
+
+    # Call get_all_instance_status with a bad id should raise an error
+    with assert_raises(EC2ResponseError) as cm:
+        conn.get_all_instance_status(instance_ids=[instance.id, "i-1234abcd"])
+    cm.exception.code.should.equal('InvalidInstanceID.NotFound')
+    cm.exception.status.should.equal(400)
+    cm.exception.request_id.should_not.be.none