diff --git a/moto/core/responses.py b/moto/core/responses.py
index e48f7df9b..726eac686 100644
--- a/moto/core/responses.py
+++ b/moto/core/responses.py
@@ -43,7 +43,8 @@ def _decode_dict(d):
 
 class BaseResponse(object):
 
-    region = 'us-east-1'
+    default_region = 'us-east-1'
+    region_regex = r'\.(.+?)\.amazonaws\.com'
 
     def dispatch(self, request, full_url, headers):
         querystring = {}
@@ -76,9 +77,11 @@ class BaseResponse(object):
         self.path = urlparse(full_url).path
         self.querystring = querystring
         self.method = request.method
-        region = re.search(r'\.(.+?)\.amazonaws\.com', full_url)
+        region = re.search(self.region_regex, full_url)
         if region:
             self.region = region.group(1)
+        else:
+            self.region = self.default_region
 
         self.headers = dict(request.headers)
         self.response_headers = headers
diff --git a/moto/sqs/responses.py b/moto/sqs/responses.py
index a151d62ca..6ab053483 100644
--- a/moto/sqs/responses.py
+++ b/moto/sqs/responses.py
@@ -16,6 +16,8 @@ MAXIMUM_VISIBILTY_TIMEOUT = 43200
 
 class QueuesResponse(BaseResponse):
 
+    region_regex = r'://(.+?)\.queue\.amazonaws\.com'
+
     @property
     def sqs_backend(self):
         return sqs_backends[self.region]
diff --git a/tests/test_sqs/test_sqs.py b/tests/test_sqs/test_sqs.py
index 7f60bb17c..fcad635d1 100644
--- a/tests/test_sqs/test_sqs.py
+++ b/tests/test_sqs/test_sqs.py
@@ -10,6 +10,7 @@ import time
 from moto import mock_sqs
 from tests.helpers import requires_boto_gte
 
+
 @mock_sqs
 def test_create_queue():
     conn = boto.connect_sqs('the_key', 'the_secret')
@@ -21,6 +22,18 @@ def test_create_queue():
     all_queues[0].get_timeout().should.equal(60)
 
 
+@mock_sqs
+def test_create_queues_in_multiple_region():
+    west1_conn = boto.sqs.connect_to_region("us-west-1")
+    west1_conn.create_queue("test-queue")
+
+    west2_conn = boto.sqs.connect_to_region("us-west-2")
+    west2_conn.create_queue("test-queue")
+
+    list(west1_conn.get_all_queues()).should.have.length_of(1)
+    list(west2_conn.get_all_queues()).should.have.length_of(1)
+
+
 @mock_sqs
 def test_get_queue():
     conn = boto.connect_sqs('the_key', 'the_secret')
@@ -113,13 +126,13 @@ def test_send_message_with_attributes():
     conn = boto.connect_sqs('the_key', 'the_secret')
     queue = conn.create_queue("test-queue", visibility_timeout=60)
     queue.set_message_class(RawMessage)
-    
+
     body = 'this is a test message'
     message = queue.new_message(body)
     message_attributes = {
-        'test.attribute_name' : {'data_type' : 'String', 'string_value' : 'attribute value'},
-        'test.binary_attribute' : {'data_type' : 'Binary', 'binary_value' : 'binary value'},
-        'test.number_attribute' : {'data_type' : 'Number', 'string_value' : 'string value'}
+        'test.attribute_name': {'data_type': 'String', 'string_value': 'attribute value'},
+        'test.binary_attribute': {'data_type': 'Binary', 'binary_value': 'binary value'},
+        'test.number_attribute': {'data_type': 'Number', 'string_value': 'string value'}
     }
     message.message_attributes = message_attributes