diff --git a/setup.py b/setup.py
index 1eb781dbc..bcbc88a20 100755
--- a/setup.py
+++ b/setup.py
@@ -78,7 +78,7 @@ else:
 _dep_PyYAML = "PyYAML>=5.1"
 _dep_python_jose = "python-jose[cryptography]>=3.1.0,<4.0.0"
 _dep_python_jose_ecdsa_pin = "ecdsa<0.15"  # https://github.com/spulec/moto/pull/3263#discussion_r477404984
-_dep_docker = "docker>=2.5.1,<=4.3.0"  # https://github.com/spulec/moto/issues/3359
+_dep_docker = "docker>=2.5.1"
 _dep_jsondiff = "jsondiff>=1.1.2"
 _dep_aws_xray_sdk = "aws-xray-sdk!=0.96,>=0.93"
 _dep_idna = "idna<3,>=2.5"