diff --git a/moto/ec2/utils.py b/moto/ec2/utils.py
index e07367081..d9ebb4258 100644
--- a/moto/ec2/utils.py
+++ b/moto/ec2/utils.py
@@ -341,15 +341,19 @@ def get_obj_tag_values(obj):
     return tags
 
 def tag_filter_matches(obj, filter_name, filter_values):
+    regex_filters = [re.compile(simple_aws_filter_to_re(f)) for f in filter_values]
     if filter_name == 'tag-key':
-        tag_names = get_obj_tag_names(obj)
-        return len(set(filter_values).intersection(tag_names)) > 0
+        tag_values = get_obj_tag_names(obj)
     elif filter_name == 'tag-value':
         tag_values = get_obj_tag_values(obj)
-        return len(set(filter_values).intersection(tag_values)) > 0
     else:
-        tag_value = get_obj_tag(obj, filter_name)
-        return tag_value in filter_values
+        tag_values = [get_obj_tag(obj, filter_name) or '']
+
+    for tag_value in tag_values:
+        if any(regex.match(tag_value) for regex in regex_filters):
+            return True
+
+    return False
 
 
 filter_dict_attribute_mapping = {
diff --git a/tests/test_ec2/test_tags.py b/tests/test_ec2/test_tags.py
index d8b585842..a25d31e2d 100644
--- a/tests/test_ec2/test_tags.py
+++ b/tests/test_ec2/test_tags.py
@@ -345,3 +345,23 @@ def test_retrieved_snapshots_must_contain_their_tags():
 
     # Check whether tag is present with correct value
     retrieved_tags[tag_key].should.equal(tag_value)
+
+
+@mock_ec2
+def test_filter_instances_by_wildcard_tags():
+    conn = boto.connect_ec2(aws_access_key_id='the_key', aws_secret_access_key='the_secret')
+    reservation = conn.run_instances('ami-1234abcd')
+    instance_a = reservation.instances[0]
+    instance_a.add_tag("Key1", "Value1")
+    reservation_b = conn.run_instances('ami-1234abcd')
+    instance_b = reservation_b.instances[0]
+    instance_b.add_tag("Key1", "Value2")
+
+    reservations = conn.get_all_instances(filters={'tag:Key1': 'Value*'})
+    reservations.should.have.length_of(2)
+
+    reservations = conn.get_all_instances(filters={'tag-key': 'Key*'})
+    reservations.should.have.length_of(2)
+
+    reservations = conn.get_all_instances(filters={'tag-value': 'Value*'})
+    reservations.should.have.length_of(2)