diff --git a/moto/ec2/models.py b/moto/ec2/models.py
index 4a9ba1460..27de681d0 100644
--- a/moto/ec2/models.py
+++ b/moto/ec2/models.py
@@ -136,7 +136,6 @@ from .utils import (
     random_transit_gateway_attachment_id,
     random_transit_gateway_route_table_id,
     random_vpc_ep_id,
-    randor_ipv4_cidr,
     random_launch_template_id,
     random_nat_gateway_id,
     random_transit_gateway_id,
@@ -3746,8 +3745,8 @@ class VPCBackend(object):
 
         # validates if vpc is present or not.
         self.get_vpc(vpc_id)
+        destination_prefix_list_id = None
 
-        service_destination_cidr = None
         if type and type.lower() == "interface":
 
             network_interface_ids = []
@@ -3760,10 +3759,10 @@ class VPCBackend(object):
 
         else:
             # considering gateway if type is not mentioned.
-            service_destination_cidr = randor_ipv4_cidr()
+            for prefix_list in self.managed_prefix_lists.values():
+                if prefix_list.prefix_list_name == service_name:
+                    destination_prefix_list_id = prefix_list.id
 
-            for route_table_id in route_table_ids:
-                self.create_route(route_table_id, service_destination_cidr)
         if dns_entries:
             dns_entries = [dns_entries]
 
@@ -3782,15 +3781,23 @@ class VPCBackend(object):
             security_group_ids,
             tags,
             private_dns_enabled,
-            service_destination_cidr,
+            destination_prefix_list_id,
         )
 
         self.vpc_end_points[vpc_endpoint_id] = vpc_end_point
 
+        if destination_prefix_list_id:
+            for route_table_id in route_table_ids:
+                self.create_route(
+                    route_table_id,
+                    None,
+                    gateway_id=vpc_endpoint_id,
+                    destination_prefix_list_id=destination_prefix_list_id,
+                )
+
         return vpc_end_point
 
     def delete_vpc_endpoints(self, vpce_ids=[]):
-        vpce_ids
         for vpce_id in vpce_ids:
             vpc_endpoint = self.vpc_end_points.get(vpce_id, None)
             if vpc_endpoint:
@@ -3800,7 +3807,7 @@ class VPCBackend(object):
                 else:
                     for route_table_id in vpc_endpoint.route_table_ids:
                         self.delete_route(
-                            route_table_id, vpc_endpoint.service_destination_cidr
+                            route_table_id, vpc_endpoint.destination_prefix_list_id
                         )
                 vpc_endpoint.state = "deleted"
         return True
@@ -3839,6 +3846,12 @@ class VPCBackend(object):
             "availability_zones": availability_zones,
         }
 
+    def get_vpc_end_point(self, vpc_end_point_id):
+        vpc_end_point = self.vpc_end_points.get(vpc_end_point_id)
+        if not vpc_end_point:
+            raise InvalidVpcEndPointIdError(vpc_end_point_id)
+        return vpc_end_point
+
 
 class PeeringConnectionStatus(object):
     def __init__(self, code="initiating-request", message=""):
@@ -4863,7 +4876,7 @@ class Route(CloudFormationModel):
         route_table,
         destination_cidr_block,
         destination_ipv6_cidr_block,
-        prefix_list=None,
+        destination_prefix_list=None,
         local=False,
         gateway=None,
         instance=None,
@@ -4875,12 +4888,15 @@ class Route(CloudFormationModel):
         carrier_gateway=None,
     ):
         self.id = generate_route_id(
-            route_table.id, destination_cidr_block, destination_ipv6_cidr_block
+            route_table.id,
+            destination_cidr_block,
+            destination_ipv6_cidr_block,
+            destination_prefix_list.id if destination_prefix_list else None,
         )
         self.route_table = route_table
         self.destination_cidr_block = destination_cidr_block
         self.destination_ipv6_cidr_block = destination_ipv6_cidr_block
-        self.prefix_list = prefix_list
+        self.destination_prefix_list = destination_prefix_list
         self.local = local
         self.gateway = gateway
         self.instance = instance
@@ -4951,7 +4967,7 @@ class VPCEndPoint(TaggedEC2Resource):
         security_group_ids=None,
         tags=None,
         private_dns_enabled=None,
-        service_destination_cidr=None,
+        destination_prefix_list_id=None,
     ):
         self.ec2_backend = ec2_backend
         self.id = id
@@ -4966,10 +4982,9 @@ class VPCEndPoint(TaggedEC2Resource):
         self.client_token = client_token
         self.security_group_ids = security_group_ids
         self.private_dns_enabled = private_dns_enabled
-        # self.created_at = utc_date_and_time()
         self.dns_entries = dns_entries
         self.add_tags(tags or {})
-        self.service_destination_cidr = service_destination_cidr
+        self.destination_prefix_list_id = destination_prefix_list_id
 
     @property
     def owner_id(self):
@@ -5169,7 +5184,7 @@ class RouteBackend(object):
         transit_gateway = None
         egress_only_igw = None
         interface = None
-        prefix_list = None
+        destination_prefix_list = None
         carrier_gateway = None
 
         route_table = self.get_route_table(route_table_id)
@@ -5184,6 +5199,8 @@ class RouteBackend(object):
                     gateway = self.get_vpn_gateway(gateway_id)
                 elif EC2_RESOURCE_TO_PREFIX["internet-gateway"] in gateway_id:
                     gateway = self.get_internet_gateway(gateway_id)
+                elif EC2_RESOURCE_TO_PREFIX["vpc-endpoint"] in gateway_id:
+                    gateway = self.get_vpc_end_point(gateway_id)
 
             try:
                 if destination_cidr_block:
@@ -5198,7 +5215,9 @@ class RouteBackend(object):
             if transit_gateway_id is not None:
                 transit_gateway = self.transit_gateways.get(transit_gateway_id)
             if destination_prefix_list_id is not None:
-                prefix_list = self.managed_prefix_lists.get(destination_prefix_list_id)
+                destination_prefix_list = self.managed_prefix_lists.get(
+                    destination_prefix_list_id
+                )
             if carrier_gateway_id is not None:
                 carrier_gateway = self.carrier_gateways.get(carrier_gateway_id)
 
@@ -5206,7 +5225,7 @@ class RouteBackend(object):
             route_table,
             destination_cidr_block,
             destination_ipv6_cidr_block,
-            prefix_list,
+            destination_prefix_list,
             local=local,
             gateway=gateway,
             instance=self.get_instance(instance_id) if instance_id else None,
@@ -5283,12 +5302,18 @@ class RouteBackend(object):
         return route_table.get(route_id)
 
     def delete_route(
-        self, route_table_id, destination_cidr_block, destination_ipv6_cidr_block=None
+        self,
+        route_table_id,
+        destination_cidr_block,
+        destination_ipv6_cidr_block=None,
+        destination_prefix_list_id=None,
     ):
         cidr = destination_cidr_block
         route_table = self.get_route_table(route_table_id)
         if destination_ipv6_cidr_block:
             cidr = destination_ipv6_cidr_block
+        if destination_prefix_list_id:
+            cidr = destination_prefix_list_id
         route_id = generate_route_id(route_table_id, cidr)
         deleted = route_table.routes.pop(route_id, None)
         if not deleted:
diff --git a/moto/ec2/responses/route_tables.py b/moto/ec2/responses/route_tables.py
index 3409320b9..ce852f59c 100644
--- a/moto/ec2/responses/route_tables.py
+++ b/moto/ec2/responses/route_tables.py
@@ -59,8 +59,12 @@ class RouteTables(BaseResponse):
         route_table_id = self._get_param("RouteTableId")
         destination_cidr_block = self._get_param("DestinationCidrBlock")
         destination_ipv6_cidr_block = self._get_param("DestinationIpv6CidrBlock")
+        destination_prefix_list_id = self._get_param("DestinationPrefixListId")
         self.ec2_backend.delete_route(
-            route_table_id, destination_cidr_block, destination_ipv6_cidr_block
+            route_table_id,
+            destination_cidr_block,
+            destination_ipv6_cidr_block,
+            destination_prefix_list_id,
         )
         template = self.response_template(DELETE_ROUTE_RESPONSE)
         return template.render()
@@ -151,9 +155,13 @@ CREATE_ROUTE_TABLE_RESPONSE = """
            <item>
               {% if route.destination_ipv6_cidr_block %}
               <destinationIpv6CidrBlock>{{ route.destination_ipv6_cidr_block }}</destinationIpv6CidrBlock>
-              {% else %}
+              {% endif %}
+              {% if route.destination_cidr_block %}
               <destinationCidrBlock>{{ route.destination_cidr_block }}</destinationCidrBlock>
               {% endif %}
+              {% if route.destination_prefix_list_id %}
+                <destinationPrefixListId>{{ route.destination_prefix_list_id }}</destinationPrefixListId>
+              {% endif %}
              <gatewayId>local</gatewayId>
              <state>active</state>
            </item>
@@ -189,19 +197,18 @@ DESCRIBE_ROUTE_TABLES_RESPONSE = """
               <item>
                 {% if route.destination_ipv6_cidr_block %}
                 <destinationIpv6CidrBlock>{{ route.destination_ipv6_cidr_block }}</destinationIpv6CidrBlock>
-                {% else %}
-                <destinationCidrBlock>{{ route.destination_cidr_block or "" }}</destinationCidrBlock>
+                {% endif %}
+                {% if route.destination_cidr_block %}
+                <destinationCidrBlock>{{ route.destination_cidr_block }}</destinationCidrBlock>
+                {% endif %}
+                {% if route.destination_prefix_list %}
+                  <destinationPrefixListId>{{ route.destination_prefix_list.id }}</destinationPrefixListId>
                 {% endif %}
                 {% if route.local %}
                   <gatewayId>local</gatewayId>
                   <origin>CreateRouteTable</origin>
                   <state>active</state>
                 {% endif %}
-                {% if route.prefix_list %}
-                  <destinationPrefixListId>{{ route.prefix_list.id }}</destinationPrefixListId>
-                  <origin>CreateRoute</origin>
-                  <state>active</state>
-                {% endif %}
                 {% if route.gateway %}
                   <gatewayId>{{ route.gateway.id }}</gatewayId>
                   <origin>CreateRoute</origin>
@@ -215,27 +222,31 @@ DESCRIBE_ROUTE_TABLES_RESPONSE = """
                 {% if route.vpc_pcx %}
                   <vpcPeeringConnectionId>{{ route.vpc_pcx.id }}</vpcPeeringConnectionId>
                   <origin>CreateRoute</origin>
-                  <state>blackhole</state>
+                  <state>active</state>
                 {% endif %}
                 {% if route.carrier_gateway %}
                   <carrierGatewayId>{{ route.carrier_gateway.id }}</carrierGatewayId>
                   <origin>CreateRoute</origin>
-                  <state>blackhole</state>
+                  <state>active</state>
                 {% endif %}
                 {% if route.nat_gateway %}
                   <natGatewayId>{{ route.nat_gateway.id }}</natGatewayId>
+                  <origin>CreateRoute</origin>
                   <state>active</state>
                 {% endif %}
                 {% if route.egress_only_igw %}
                   <egressOnlyInternetGatewayId>{{ route.egress_only_igw.id }}</egressOnlyInternetGatewayId>
+                  <origin>CreateRoute</origin>
                   <state>active</state>
                 {% endif %}
                 {% if route.transit_gateway %}
                   <transitGatewayId>{{ route.transit_gateway.id }}</transitGatewayId>
+                  <origin>CreateRoute</origin>
                   <state>active</state>
                 {% endif %}
                 {% if route.interface %}
                   <networkInterfaceId>{{ route.interface.id }}</networkInterfaceId>
+                  <origin>CreateRoute</origin>
                   <state>active</state>
                 {% endif %}
               </item>
diff --git a/moto/ec2/utils.py b/moto/ec2/utils.py
index 8ceeb1e16..37de6073a 100644
--- a/moto/ec2/utils.py
+++ b/moto/ec2/utils.py
@@ -257,9 +257,13 @@ def random_ipv6_cidr():
     return "2400:6500:{}:{}::/56".format(random_resource_id(4), random_resource_id(4))
 
 
-def generate_route_id(route_table_id, cidr_block, ipv6_cidr_block=None):
+def generate_route_id(
+    route_table_id, cidr_block, ipv6_cidr_block=None, prefix_list=None
+):
     if ipv6_cidr_block and not cidr_block:
         cidr_block = ipv6_cidr_block
+    if prefix_list and not cidr_block:
+        cidr_block = prefix_list
     return "%s~%s" % (route_table_id, cidr_block)
 
 
diff --git a/tests/terraform-tests.success.txt b/tests/terraform-tests.success.txt
index 83394e12e..531a23e2b 100644
--- a/tests/terraform-tests.success.txt
+++ b/tests/terraform-tests.success.txt
@@ -115,6 +115,8 @@ TestAccAWSRouteTable_MultipleRoutes
 TestAccAWSRouteTable_PrefixList_To_InternetGateway
 TestAccAWSRouteTable_VpcMultipleCidrs
 TestAccAWSRouteTable_IPv4_To_CarrierGateway
+TestAccAWSRouteTable_IPv4_To_InternetGateway
+TestAccAWSRouteTable_GatewayVpcEndpoint
 TestAccAWSSsmDocumentDataSource
 TestAccAwsEc2ManagedPrefixList
 TestAccAWSEgressOnlyInternetGateway
diff --git a/tests/test_ec2/test_route_tables.py b/tests/test_ec2/test_route_tables.py
index 8b92b4b4d..f7c07a5a1 100644
--- a/tests/test_ec2/test_route_tables.py
+++ b/tests/test_ec2/test_route_tables.py
@@ -502,7 +502,7 @@ def test_routes_vpc_peering_connection():
     new_route.gateway_id.should.be.none
     new_route.instance_id.should.be.none
     new_route.vpc_peering_connection_id.should.equal(vpc_pcx.id)
-    new_route.state.should.equal("blackhole")
+    new_route.state.should.equal("active")
     new_route.destination_cidr_block.should.equal(ROUTE_CIDR)
 
 
@@ -748,13 +748,19 @@ def test_create_route_with_egress_only_igw():
     route_table = ec2.create_route_table(VpcId=vpc.id)
 
     ec2_client.create_route(
-        RouteTableId=route_table.id, EgressOnlyInternetGatewayId=eigw_id
+        RouteTableId=route_table.id,
+        EgressOnlyInternetGatewayId=eigw_id,
+        DestinationIpv6CidrBlock="::/0",
     )
 
     route_table.reload()
-    eigw_route = [r for r in route_table.routes if r.destination_cidr_block == ""][0]
-    eigw_route.egress_only_internet_gateway_id.should.equal(eigw_id)
-    eigw_route.state.should.equal("active")
+    eigw_route = [
+        r
+        for r in route_table.routes_attribute
+        if r.get("DestinationIpv6CidrBlock") == "::/0"
+    ][0]
+    eigw_route.get("EgressOnlyInternetGatewayId").should.equal(eigw_id)
+    eigw_route.get("State").should.equal("active")
 
 
 @mock_ec2
diff --git a/tests/test_ec2/test_vpcs.py b/tests/test_ec2/test_vpcs.py
index 002e9aac6..13151f64d 100644
--- a/tests/test_ec2/test_vpcs.py
+++ b/tests/test_ec2/test_vpcs.py
@@ -955,13 +955,13 @@ def test_delete_vpc_end_points():
     route_table = ec2.create_route_table(VpcId=vpc["Vpc"]["VpcId"])
     vpc_end_point1 = ec2.create_vpc_endpoint(
         VpcId=vpc["Vpc"]["VpcId"],
-        ServiceName="com.amazonaws.us-east-1.s3",
+        ServiceName="com.amazonaws.us-west-1.s3",
         RouteTableIds=[route_table["RouteTable"]["RouteTableId"]],
         VpcEndpointType="gateway",
     )["VpcEndpoint"]
     vpc_end_point2 = ec2.create_vpc_endpoint(
         VpcId=vpc["Vpc"]["VpcId"],
-        ServiceName="com.amazonaws.us-east-2.s3",
+        ServiceName="com.amazonaws.us-west-1.s3",
         RouteTableIds=[route_table["RouteTable"]["RouteTableId"]],
         VpcEndpointType="gateway",
     )